Maklakov Lab

University of East Anglia

- · United Kingdom

ERC-funded
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ERC Consolidator Grant · 2020

Testing the Evolutionary Consequences of Haploid Selection in Animals

Selection occurring during the haploid gametic phase of any sexually reproducing eukaryote may have far-reaching consequences for major biological processes. Selection acting on a haploid genome results in efficient removal of deleterious alleles and rapid fixation of beneficial alleles, which in turn affect adaptation, genetic load and the evolution of recombination rates. Despite their potential importance, we know surprisingly little about the genetic processes occurring during the time window after meiosis until the fusion of male and female pronuclei. This is particularly true for haploid selection in the gametes of predominantly diploid animals. Male gametes (sperm) are produced in…

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