Lenormand Lab

Research focus

ERC Advanced Grant · 2022

The evolution of cis and trans-regulators in eukaryotes

Gene regulation plays an essential role in shaping species differences and modulating phenotypes across development and environmental conditions. It essentially works through the recruitment of trans-acting intermediates to cis-acting DNA sequences affecting the expression of the nearby gene. While gene expression regulation is central in molecular, cellular, developmental, and system biology, its detailed mechanisms have relatively little been incorporated into modern evolutionary theory. I previously discovered two processes specific to gene expression evolution in diploids, cis-regulator runaway and divergence. They arise because of (i) transient dominance modifications that…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.