ERC Consolidator Grant · 2022
Evaluating how pleiotropy influences genetic and developmental evolution by using rodent teeth
Pleiotropy is the phenomenon of one gene affecting several phenotypic traits, such as different organs. Mutations advantageous in one organ often have antagonistic effects in others. Recent theoretical and empirical data suggest adaptation proceeds with such pleiotropic mutations if they are compensated during development. I think that pleiotropy may promote the fast divergence of developmental gene expression and cis-regulatory regions while selecting for such compensations. To test this, my lab’s model, the upper and lower molars in rodents, will be ideal to: -Link variation in genes, development and shape, and track compensations in developmental processes. -Focus on a tractable case of…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.