ERC Consolidator Grant · 2022
Role of epistatic interactions in evolution
The distribution of fitness effects of mutations is vital to our understanding of rates and patterns of adaptation. Population genetics and mutation accumulation experiments have given us insight into the distribution of fitness effects of single mutations. However, mutations often interact with each other. This is called epistasis. The role of epistatic interactions in adaptation has remained controversial. Yet, the distribution of epistatic effects is as fundamental as distribution of mutational effects themselves. Without knowing the distribution of epistatic effects, we can’t calculate the average fitness effect of a given mutation across multiple genetic backgrounds. Moreover, if…
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