Sanchez Lab

Spanish National Research Council (CSIC)

Comunidad de Madrid (ES3) · Spain

ERC-funded
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ERC Consolidator Grant · 2022

Mapping vast functional landscapes with single-species resolution: a new approach for precision engineering of microbial consortia

Given a list of candidate species, which community should one form to optimize a target function? Answering this fundamental ecological question is particularly urgent in the emerging field of synthetic microbial ecology, where it would dramatically improve our ability to design multi-species consortia for biotechnological applications. An empirical solution is out of reach, due to the astronomical number of possibilities: one could form ~1E30 possible assemblages from just 100 species. To provide a solution, ECOPROSPECTOR will borrow state-of-the-art ideas from Evolutionary Systems Biology and the theory of Fitness Landscapes, where similarly vast combinatorial spaces must be explored to…

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