ERC Advanced Grant · 2023
Antibiotics of the future: are they prone to bacterial resistance?
Although several new antibiotic candidates are in the clinical pipeline, the future evolution of resistance in bacteria may render them ineffective. This project aims to develop a framework for forecasting the long-term effectiveness of new antibiotic candidates. For this purpose, we will decipher the general principles shaping bacterial resistance to a wide range of antibiotic candidates currently in development. Using recently developed methods in our laboratory, we will study resistance evolution in bacterial ESKAPE pathogens at unprecedented resolution and address four specific aims. First, we explore the shared features of antibiotics with limited susceptibility to resistance. Second,…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.