Groussin Lab

University Hospital Schleswig-Holstein (UKSH)

Schleswig-Holstein (DEF) · Germany

ERC-funded
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ERC Consolidator Grant · 2023

Origin, evolution and function of bacterial extracellular vesicles in the human host-gut microbiome system

Bacterial extracellular vesicles (BEVs) are small membrane vesicles secreted by a diverse range of bacteria that act as bioactive nanocarriers of a high diversity of proteins, lipids and nucleic acids. BEVs have mostly been studied in pathogenic bacterial models, owing to their causal role in pathogenicity. Compared to other microbial features, such as taxa, genes or metabolites, BEVs secreted by the large diversity of commensal bacterial species of the human gut microbiota have received little attention so far, leaving their influence upon gut microbial ecology and human health almost entirely unknown. We hypothesize that gut BEVs and their molecular cargos (i.e. the gut bacterial…

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