ERC Consolidator Grant · 2024
How domain mimicry shapes genetic conflicts between hosts and viruses
Viral mimicry is a prevalent evolutionary mechanism for the acquisition of host-protein domains in order to hijack cellular pathways. By leveraging the similarity between the original host and the mimicked domain, the viral mimic forms interactions with host proteins. This introduces genetic conflict since these interactions are advantageous for the virus and deleterious for the host. The host is limited in its capacity to avoid mimics because evolving to escape them can disrupt the host interactome. Elucidating the way in which hosts evolve in the face of mimicry, and the constraints placed on viral mimics, are central to understanding the evolution of genetic conflicts. To address these…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.