ERC Consolidator Grant · 2024
Linking vector, virus and immunity to the evolving fitness of dengue virus
Across pathogens, it remains unclear why some lineages persist while others die out. Population immunity pressure coupled with relative abilities to infect and disseminate in hosts are likely to play a critical role. There are key data and methodological gaps that prevent us from identifying and quantifying drivers of pathogen fitness. We need robust measures of fitness and be able to apply these measures to sequences from the same ecological disease system over many years. We also need to understand how an individual's immunity responds, if at all, to ongoing exposures by continuously changing pathogens. Finally, we need appropriate methods that can integrate candidate drivers of fitness…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.