Sebé-Pedrós Lab

Centre for Genomic Regulation

Este (ES5) · Spain

ERC-funded
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ERC Consolidator Grant · 2024

Animal cell types across evolutionary timescales: from regulatory characters to cell phylogenies

Cell types are the basic constituents of animal multicellularity, with each type defined by a gene regulatory program that specifies cell function and structure. Thus, understanding cell type diversity is key to explaining animal adaptation and evolution. However, despite recent advances in the molecular characterization of cell types, the phylogenetic relationships between animal cell types remain obscure—mainly because we do not understand how the different elements of a cell type identity program (e.g. transcription factors and regulatory sequences) change over time and how these changes translate into cellular novelties. This project will bridge the gap between cell type micro- and…

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