Koh Lab

Pasteur Institute

Ile-de-France (FR1) · France

ERC-funded
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ERC Starting Grant · 2024

The Multitudes of Mosquito Viruses and Their Impact on Arbovirus Disease Ecology

The mosquito virome constitutes not only human pathogenic arthropod-borne viruses (arboviruses) but also mosquito-specific viruses, whose host range is restricted to the mosquito. While metagenomics studies have revealed the mosquito virome to be richly diverse and abundant, our knowledge of these viruses is mostly limited to genome sequence information, and we have little insight into their biology and interactions with the mosquito host. Importantly, the cellular and immunological mechanisms by which mosquitoes deal with multitudes of concurrent viral infections remain to be understood. Furthermore, mosquito-specific viruses have been reported to inhibit or enhance co-infecting…

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