ERC Advanced Grant · 2016
Translational implications of the discovery of brain-draining lymphatics
In 2010, 800 billion Euros was spent on brain diseases in Europe and the cost is expected to increase due to the aging population. – Here I propose to exploit our new discovery for research to alleviate this disease burden. In work selected by Nature Medicine among the top 10 ”Notable Advances” and by Science as one of the 10 ”Breakthroughs of the year” 2015, we discovered a meningeal lymphatic vascular system that serves brain homeostasis. I want to reassess current concepts about cerebrovascular dynamics, fluid drainage and cellular trafficking in physiological conditions and in Alzheimer’s disease (AD) models in mice and in postmortem tissues in humans. First, we will study the…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.