Högberg Lab

Karolinska Institute

Östra Sverige (SE1) · Sweden

ERC-funded
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ERC Advanced Grant · 2022

The sequencing microscope - a path to look at the molecules of biology

The goal of biological research is to understand how life works. Although progress is fast, there seems to be an infinity of things we do not understand. When it comes to understanding tissue from the bottom up, our knowledge leaves much to desire. Feynman claimed that “It is very easy to answer many of these fundamental biological questions; you just look at the thing!” well the problem is that looking at the thing is the problem. Microscopy might never give us the possibility to directly see DNA- or RNA-sequence. For this, the community has evolved extraordinarily powerful sequencers. Today one man can routinely read millions of sequences on a weekly basis. And likely soon, we will read…

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