ERC Consolidator Grant · 2024
Direct in utero engineering of mouse models
Mouse models are a gold standard for life sciences research, spanning developmental biology, cancer studies, and pre-clinical testing, but they also have important limitations. Mouse colony maintenance is expensive, and the large colonies needed are ethically problematic. Approaches aiming for cell-type specific manipulations can be confounded by leaky promoters, off-target/unknown promoter expression, endogenous Cre sites, and Cre toxicity. Finally, mouse strains generated in different inbred genetic backgrounds yield confounding results when interbred, or necessitate extensive back-crossing, and again - large usage of mice. An alternative strategy to generate mouse models, circumventing…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.