ERC Consolidator Grant · 2017
The occurrence of therapeutic resistance is a major cause for the small effect on overall survival showed by targeted cancer therapies. Whilst experimental strategies to evaluate available treatments have been faced by an ever increasing number of possible combinations, computational approaches have been challenged by the lack of a framework able to model the multiple interactions encompassed by the three major factors affecting therapeutic resistance: selection of resistant clones, adaptability of gene signalling networks, and a protective and hypoxic tumour microenvironment. Here I propose a novel modelling framework, Agent-Based Modelling of Gene Networks, which brings together powerful…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.