ERC Consolidator Grant · 2017
Harnessing clonal evolution in chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL), the most common leukemia in adults, is addicted of interactions with the microenvironment. The B-cell receptor (BCR) is one of the most important surface molecules that CLL cells use to gain oncogenic signals from the microenvironment. The critical role of BCR signaling for the pathogenesis of CLL is supported by the therapeutic success of ibrutinib, a targeted agent that disrupts the BCR pathway. Beside microenvironment-promoted oncogenic signals, the biology of CLL is also driven by molecular lesions and clonal evolution, that mark CLL progression and treatment resistance. The interconnection between microenvironment-promoted oncogenic signals and…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
← All labs at Foundation for the Research and Cure of Lymphoma in Ticino