ERC Advanced Grant · 2019
MOVING FROM BIOMARKERS TO MECHANISM ORIENTED PREVENTION OF CARDIOMETABOLIC DISEASE
Increasing occurrence of obesity and diabetes is the major threat to cardiovascular health of our century. Whereas the field is saturated with “omics” strategies aimed at improving prediction of cardiometabolic disease (CMD), mechanism-orientated prevention strategies, which is what the population calls for, are lacking. We here propose three completely new and high-risk strategies to prevent CMD in large subsets of the population, who have elevated risk due to measurable endocrine abnormalities. SUBPROJECT 1: We test if the increased CMD risk linked to high levels of the intestinal fat absorption and storage promoting hormone neurotensin (NTS), can be improved by: (A) blockade of NTS using…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.