Ruijter Lab

University Medical Center Utrecht

West-Nederland (NL3) · Netherlands

ERC-funded
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Research focus

ERC Consolidator Grant · 2019

Uncovering the epigenetic signature of female-specifiC biological networks and key driver genes of coronary ArteRy diseasE

Cardiovascular disease causes 51% of deaths in women and 42% of deaths in men in Europe. Women are contributing mostly to the worrying trend of increases in hospitalizations for coronary artery disease (CAD) at younger ages. Missed and delayed diagnoses in women are more common than in men, as the pathophysiology of CAD in women is different than in men. Men often have atherosclerotic plaque rupture as underlying mechanism for CAD whereas women more often suffer from plaque erosion. Plaque erosion refers to thrombus formation on top of an intact non-ruptured plaque in the coronary artery. Early recognition of plaque erosion will, therefore, specifically aid in the diagnosis of CAD in women.…

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