ERC Starting Grant · 2019
Redefining the esophageal stem cell niche – towards targeting of squamous cell carcinoma
Cancer develops from mutations in stem and progenitor cells. Patients suffering from esophageal squamous cell carcinoma are commonly treated by a combination of chemotherapy and esophagectomy, a debilitating surgical procedure. My group have identified heterogeneity within the esophageal progenitor population in homeostasis which is likely to have implications for the development of squamous cell carcinomas of the esophagus, lead to targeted therapeutic strategies and hopefully reduce the need for surgical intervention. Stem and progenitor cells reside in a complex microenvironment, or niche, that is instructive in determining cell fate during homeostasis and tumor initiation. In the…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.