Ruigrok Lab

University Medical Center Utrecht

West-Nederland (NL3) · Netherlands

ERC-funded
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Research focus

ERC Starting Grant · 2019

Early recognition of intracranial aneurysms to PRevent aneurYSMal subarachnoid hemorrhage

Intracranial aneurysms usually go undetected until rupture occurs leading to aneurysmal subarachnoid hemorrhage (ASAH), a type of stroke with devastating effects. Early detection and preventive treatment of aneurysms fall short as we do not know who is it at risk and why, as we have insufficient insight in the contribution and interplay of genetic, environmental and intermediate phenotypic risk factors. Given the rarity of the disease, there is a paucity of large and rich cohorts to study risk factors separately with sufficient power. To add to the problem, my preliminary findings suggest disease heterogeneity with subgroup specific risk factors for aneurysms. The sex-related heterogeneity…

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