Hauer Lab

University Hospital Munich \Klinikum rechts der Isar\

Bayern (DE2) · Germany

ERC-funded
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Research focus

ERC Starting Grant · 2019

Prevention of childhood Acute Lymphoblastic Leukemia immunology links oncology

PreventALL analyzes genetic risk in infection induced ALL and will pioneer leukemia prevention. Acute lymphoblastic leukemia (ALL) is the most common type of childhood cancer and it remains a major cause of death in children aged 2-6 years in high-income countries. Exposure to infection, as a potential trigger for the development of childhood ALL was theorized a century ago with several possibilities of exposure to infection in infancy. Consequently, the overall objectives of PreventALL is to systematically analyze postnatally the genetic risk to develop B-cell-precursor (BCP)-ALL and to decipher the infectious mechanism by which exposure to infection causes BCP-ALL. This opens a new…

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