ERC Advanced Grant · 2020
Plasma epigenomics: A new liquid biopsy paradigm
Genomic DNA is packaged by histone proteins that carry a multitude of post-translational modifications, which reflect cellular transcriptional states. When cells die, fragmented chromatin retaining histone modifications is released to the circulation. Recently, we pioneered chromatin immunoprecipitation of cell-free nucleosomes carrying active chromatin marks followed by sequencing (cfChIP-seq). Our results show that cfChIP-seq provides multidimensional epigenetic information and that the plasma epigenome contains rich information about the identity and the transcriptional state of the originating cells. Liquid biopsies already entered the clinical practice, yet current methodologies use…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.