Aziz Lab

Research focus

ERC Starting Grant · 2021

Tandem Repeats Associated with Neurogenomic Somatic Instability and Neurodegeneration

Dementia and other neurodegenerative diseases are among the leading causes of disability worldwide and have an immense societal impact due to lack of effective treatments. For developing better preventive and therapeutic strategies, it is essential to clarify their still largely elusive genetic basis and pathophysiology. Emerging insights from the study of rare hereditary repeat expansion disorders caused by elongations of repetitive DNA sequences ("tandem repeats" (TRs)) indicate that TRs could induce instability of neuronal DNA ("neurogenomic somatic instability"), and thereby instigate molecular changes that lead to neuronal degeneration. However, the role of highly prevalent TR…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.