Nonnekens Lab

Erasmus Medical Center Rotterdam

West-Nederland (NL3) · Netherlands

ERC-funded
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Research focus

ERC Starting Grant · 2021

Deciphering the radiobiology of targeted radionuclide therapy: from subcellular to intra-tumoural analyses

Background and unmet need Targeted radionuclide therapies (TRTs) are a promising modality to treat patients with metastasized cancer. TRTs function via systemic administration of radiolabelled molecules (α- and β-particle emitters) designed to target tumour cells. However, the radiobiological effects of TRTs are poorly understood, and rational design of new modalities based on underlying cellular mechanisms is therefore not possible, resulting in suboptimal treatment strategies. Since most patients with advanced cancer cannot be cured at the moment, it is therefore my ultimate goal to improve TRT. Aim My ERC project aims to identify and quantitate specific radiobiological mechanisms of…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.

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