ERC Starting Grant · 2021
Low frequency nanobubbles-enhanced noninvasive transcranial ultrasound for brain cancer therapy
One of the worst diagnoses in oncology is a malignant brain tumor, with survival rates that are dismal. Noninvasive surgery can be achieved using histotripsy, a local, nonthermal ultrasound (US) surgical method that uses short, high-intensity?focused US energy to mechanically ablate deep tissues through cavitation, while leaving the surrounding heathy tissues unaffected. However, brain therapy histotripsy is currently limited due to the extremely high pressures that it requires. I propose to develop a breakthrough technology for the treatment of glioblastoma (GBM) using nanobubble (NB)-mediated transcranial histotripsy combined with blood?brain barrier (BBB) opening. NBs will be coupled…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.