Martinez-Gonzalez Lab

University of Navarra

Noreste (ES2) · Spain

ERC-funded
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ERC Advanced Grant · 2022

A non-inferiority randomized trial testing an advice of modeA non-inferiority randomized trial testing an advice of moderate drinking pattern versus advice on abstention on major disease and mortality

Europeans are the largest alcohol consumers. Policymakers and clinicians are currently perplexed on how to reduce alcohol harms in drinkers, due to contradictory guidelines: abstention is proposed as the healthiest option by many health advocates, stating that “there is no safe level of alcohol intake”; but most nonrandomized studies found lower all-cause mortality and other outcomes in moderate drinkers than in abstainers among subjects >50 years. However, potential biases may compromise these latter studies, particularly when effects are null or moderate. A large pragmatic randomized controlled trial (RCT) of realistic advice aimed to change behavior addressing clinical endpoints is long…

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