ERC Consolidator Grant · 2022
Rational and Simulation-Supported Design of Inhalable RNA Nanocarrier
The overarching goal of RatInhalRNA is to computationally predict and develop efficient formulations for pulmonary RNA therapy. New RNA formulations are imperative for clinical RNA delivery beyond the liver. The lung offers undruggable targets which could be treated with RNA therapeutics. However, approved siRNA formulations are not suited for pulmonary delivery due to instability in lung surfactant and during nebulization. Hence, it is my aim to rationally design inhalable and biocompatible polymer-based siRNA formulations for efficient siRNA delivery to the lung. While biomaterials are commonly optimized empirically via one-variable-at-a-time experimentation, I am the first to combine…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.