ERC Consolidator Grant · 2022
Non-invasive staining of tissue microstructure in temporal lobe epilepsy using in- vivo MRI
Ex-vivo histology is the gold standard to investigate human brain microstructure. However, its invasive nature precludes its use in monitoring disease progression and the investigation of the pathophysiological origin of neurological disorders. MRStain will address this shortcoming by exploiting the sensitivity of the Magnetic Resonance Imaging (MRI) signal to estimate aggregated histological metrics in the human brain non-invasively. Like established histology staining methods (e.g., myelin-basic protein), MRStain will be sensitive to changes in cellular populations, axons, myelin, and iron. This will be achieved by augmenting the MRI measurements with computational biophysical models,…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.