ERC Consolidator Grant · 2022
The concept of “exposome” encompasses all human disease determinants encountered during the life course. The exposome induces epigenetic modifications (e.g., DNA methylation). Several studies have investigated how repetitive elements (REs) can be switched on in response to environmental stimuli, but have started from the assumption that altered RE methylation is always detrimental to the health of the affected individual. MAMELI proposes an alternative hypothesis that some REs are plastic entities that respond physiologically to the environment; consequently, the ability of DNA to adapt to environmental triggers can be monitored. To test this hypothesis, the MAMELI project will enroll 6200…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.