Weingärtner Lab

Delft University of Technology

West-Nederland (NL3) · Netherlands

ERC-funded
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ERC Starting Grant · 2022

MRI-based ID of the Vasculature across the Heart-Brain Axis

Microvascular impairment is a hallmark of many of today’s most burdening diseases, including forms of ischemic heart disease, stroke, and dementia. It is also the most promising candidate to explain the link between cardiovascular and brain disease (so-called heart-brain axis). However, only histology provides comprehensive assessment of the microvasculature, and is rarely available in vivo as it requires invasive biopsy. The lack of early, non-invasive markers limits our pathophysiological understanding and crucially affects treatment success, as preventive intervention is the only successful clinical management strategy available. With a major leap in Magnetic Resonance Imaging (MRI)…

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