ERC Starting Grant · 2022
Precision oncology of spatial immune escape mechanisms in ovarian cancer
Tumor progression is dependent on the ability of Tumor progression is dependent on the ability of malignant cells to escape the recognition and attack by the host immune system. The development of more efficient cancer immunotherapies has been hampered by the perplexity of immune escape mechanisms. I hypothesize that tumor genetic drivers dictate the immune escape mechanisms, and that these mechanisms can be exploited to develop more effective immunotherapeutic strategies for patients with high-grade serous ovarian cancer (HGSC), the most common and lethal ovarian cancer. My group has developed an optimized algorithm based on homologous recombination (HR) DNA repair deficiency to enable…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.