Keszthelyi Lab

Maastricht University

Zuid-Nederland (NL4) · Netherlands

ERC-funded
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ERC Starting Grant · 2022

Rediscovering the Wanderer: restoration of sympathico-vagal disbalance in irritable bowel syndrome by neuromodulation – a novel therapeutic concept

Common colloquial phrases like ‘gut feeling’ or ‘butterflies in my belly’ are not just idioms but reflect on the unique communication between gut and brain. The principal interface for this interaction is the autonomic nervous system — a largely subconscious system that manages bodily functions through a delicate balance between its two branches: the sympathetic and parasympathetic nervous systems. The vagus nerve is the main component of the latter. Diminished vagal tone resulting in increased sensitivity to pain is characteristic for many chronic pain disorders, including irritable bowel syndrome (IBS). People with IBS have frequent and often severe abdominal pain. While its etiology…

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