Hägerling Lab

Charite - University Hospital Berlin

Berlin (DE3) · Germany

ERC-funded
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Research focus

ERC Starting Grant · 2022

Precision medicine approach to rare vascular malformations to enhance understanding, diagnostics and therapy

Vascular malformations are clinically very heterogeneous ranging from small local ‘birthmarks’ to life-threatening entities affecting entire limbs, organs or larger parts of the human body. Often, these conditions require surgical and/or pharmacological intervention to prevent further disease progression and to increase patients’ quality of life. Therefore, an accurate diagnosis is crucial for appropriate treatment and management. However, our current knowledge on vascular malformations is very limited, making diagnosis and treatment very difficult due to: 1) An inadequate understanding of the underlying histological alterations causing the phenotype. 2) Very limited genetic diagnostic…

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