Kurakula Lab

Research focus

ERC Starting Grant · 2022

Mending sex differences: Unravelling the female predominance in pulmonary hypertension

Pulmonary hypertension (PH) is a rare but progressive fatal disease characterized by accumulation of persistently activated cell types in the pulmonary vascular wall exhibiting abnormal expression of genes driving proliferation, inflammation, and metabolism. The currently used vasodilatory therapies have little or no impact on this activated phenotype and therefore offer no cure or even substantial survival benefit. PH has a high female predominance (3:1 to 9:1). This proposal aims to understand the mechanism behind the high female predominance to identify novel therapeutic targets to attenuate disease progression in male and female PH patients. Female predominance can be linked to sex…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.