ERC Advanced Grant · 2023
Targeting mechanisms of Thrombo-inflammation
The recent Covid-19 pandemic dramatically illustrated (i) the clinical relevance of thrombo-inflammation (the interplay of coagulation and inflammation) and (ii) our limited understanding of molecular mechanisms of thrombo-inflammation. Thrombo-inflammation is a frequent disease-driving mechanism, impairing out-come of viral or bacterial infection, cardiovascular disease, cancer and other diseases. The lack of mechanistic insights hampered the development of specific therapies. My group recently discovered a new molecular link between coagulation and inflammation that addresses this enormous unmet medical need: the initiator of coagulation, tissue factor (TF, F3, CD142), forms a previously…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.