Berghe Lab

University of Leuven

Vlaams Gewest (BE2) · Belgium

ERC-funded
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Research focus

ERC Advanced Grant · 2023

Concomitant Reversal of Adrenal Insufficiency and Muscle Weakness to Enhance Recovery from Prolonged Critical Illness

Sepsis, complicated surgery or extensive trauma cause hyperinflammation-induced critical illness which requires vital organ support in an intensive care unit (ICU) in order to avoid imminent death. Although modern intensive care has reduced mortality, a large number of survivors continue to require such supportive care in the ICU sometimes for weeks or months. Once in this prolonged phase, typical ICU-acquired morbidities such as lingering organ failure, muscle wasting and weakness and vasopressor- and ventilator-dependency become the main drivers of poor short- and long-term outcome irrespective of the initial diagnosis upon admission. Research from our group has focused on two of these…

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