Stokholm Lab

Research focus

ERC Consolidator Grant · 2023

Restoration of the gut microbiome after delivery by caesarean section to prevent asthma

Associations between caesarean section (CS) and childhood asthma may be mediated through microbial changes. In 700 children followed prospectively from birth, I recently showed that microbial perturbations after delivery by CS explain the delivery mode-associated risk of developing asthma in the first 6 years of life. CS was associated with more than a doubled risk of later asthma and allergic sensitization as well as immense compositional changes in the gut microbiota. An increased asthma risk was only found in children born by caesarean section, if their microbiome did not normalize by age 1 year, suggesting that a healthy microbial maturation can alleviate the child’s increased asthma…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.