Salminen Lab

University of Turku

Manner-Suomi (FI1) · Finland

ERC-funded
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Research focus

ERC Consolidator Grant · 2023

Oral antibiotic outpatient therapy vs. placebo in the treatment of uncomplicated acute appendicitis: a randomized double-blind placebo-controlled noninferiority trial

Acute appendicitis is one of the most common surgical emergencies worldwide. For over a century, surgical removal of the appendix has been considered the only treatment option. Landmark trials by our experienced APPAC team have shown that imaging confirmed uncomplicated acute appendicitis is not a surgical emergency defining antibiotics to safe and effective also with only oral antibiotics avoiding unnecessary surgeries resulting in major cost and resource savings. However, the role of antibiotics remains a major knowledge gap. Our pilot APPAC III showed that even symptomatic treatment (placebo) may be sufficient warranting a larger noninferiority trial to assess whether antibiotics are…

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