ERC Advanced Grant · 2024
Connecting Joint Function to Chondrocyte Biology in Knee Osteoarthritis
Osteoarthritis (OA), a degenerative joint disease, debilitates the lives of 242 million people globally but remains without a cure. The knee joint is most frequently affected, causing pain, loss of joint function, and reduced quality of life. OA-CONNECT instigates an innovative approach to understanding the fundamental cause of OA by posing a question that could previously never be answered: ‘What causes mechanical loads to switch from supporting to disrupting cartilage health in OA?’ OA-CONNECT introduces a unique, integrated approach CONNECT-ing joint function to chondrocyte biology to unravel the OA Mechanome, the maladaptive dynamic interplay of mechanical and biological drivers of OA…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.