ERC Consolidator Grant · 2024
Re-Defining early Parkinson’s disease
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, but current diagnostic criteria identify individuals late, impeding the development of neuroprotective therapies: There is the critical yet unmet need to identify the disease onset timely and to define the inception of pathology. Advancing recognition of early motor deterioration and coupling it with biological evidence of pathological α-synuclein will overcome present barriers and tackle the questions when and where PD starts. Isolated REM sleep behavior disorder, confidently detectable by polysomnography, signals an early α-synucleinopathy. Overseeing a large cohort, I will integrate multimodal motor data on…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.