Thackeray Lab

Hannover Medical School

Niedersachsen (DE9) · Germany

ERC-funded
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ERC Consolidator Grant · 2024

Molecular Imaging to Guide Repair and Advance Therapy: Targeting the inflammation-fibrosis axis in ischemic heart disease and remote organs

Myocardial infarction triggers a complex interplay between inflammation and fibroblast activation, which contributes to success or failure of adequate repair. Targeted therapeutic approaches to modulate these processes have not yet been implemented clinically. The dynamic and multicellular nature of the inflammatory and fibrotic repair process in the heart is thought to be variable among individuals. Additionally, cardiac injury and treatment affect distant organs through systems-based interaction. In MIGRATe, I will explore non-invasive molecular imaging approaches to interrogate inflammatory cell populations and fibroblast activation in the heart and networking organs, for precise…

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