ERC Starting Grant · 2024
Investigating virus-induced morbidity in filarial infections
Filarial parasites cause over 200 million infections globally. Filarial morbidity was presumably limited to the skin, eyes, and lymphatic vessels. However, my research generated evidence that Onchocerca volvulus infection also induces neurological disease including Onchocerciasis-Associated Epilepsy (OAE). However, the causal mechanisms for neurological symptoms linked to O. volvulus infection are still unknown. Recently my research group co-discovered a virus (OVRV1) within O. volvulus. Being related to the rabies virus family, OVRV1 could potentially cause OAE. I will investigate the clinical implications of this virus in >1600 persons from 3 affected countries. Case-control studies will…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.