Rius Lab

Institute for Bioengineering of Catalonia

Este (ES5) · Spain

ERC-funded
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ERC Starting Grant · 2024

Lifetime Metabolomics for Paediatric Liver Cancer Detection and Therapy Assessment Using Organ-on-Chip Platforms

Understanding cancer metabolism at the individual patient level is central to making accurate early-stage diagnoses and providing effective patient-specific treatments. While some methods do exist to study intra-cell metabolomics and inter-cell metabolic flux alterations (e.g., PET, MRI), their scalability and sensitivity is limited, hindering reliable investigations long-term. LIFETIME aims to develop a single platform for "lifetime metabolomics", where the metabolic fingerprint of a disease is traced throughout patient onset in vivo, analysis ex vivo, and through to treatment. Technologically this involves rapid metabolomic profiling of the cancer model, using microfluidic…

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