ERC Starting Grant · 2024
Harnessing Hematopoietic Stem Cell Breakthroughs to Pioneer Advances in Transplantation Therapies
Hematopoietic stem cell transplantation (HSCT) is a groundbreaking therapy that has transformed the treatment of severe hematological and immune disorders. It involves infusing healthy or corrected hematopoietic stem cells (HSCs) into a patient to restore their blood cell production. Despite its remarkable success, HSCT is currently limited to the most severe cases due to several key challenges. These bottlenecks include inefficient HSC mobilization, limited engraftment leading to insufficient clonal diversity, and the toxicity of chemotherapy-based conditioning regimens. This comprehensive proposal outlines a transformative approach to address these limitations head-on, enhancing both the…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.