Salker Lab

University of Tuebingen

Baden-Württemberg (DE1) · Germany

ERC-funded
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Research focus

ERC Consolidator Grant · 2025

The use of reconstructed assembloids, multimodal single cell sequencing and nanosensor development to study human implantation and pregnancy loss.

Human reproductive failure affects one in six couples globally and is a serious global socio-economic concern. Human pregnancy requires implantation of an embryo into the endometrium- yet many unknown or deregulated factors may prevent implantation from occurring. Without understanding the root cause, treating reproductive failure often becomes a guessing game. Most implantation-related events remain uncharted territory, making implantation a true ‘black box’ in biology. The central questions to be addressed in this ERC-proposal, are, firstly how does the human endometrium sense embryos and, secondly how is this selection influenced by the maternal uterine microenvironment. Understanding…

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