Lasarte Lab

Research focus

ERC Starting Grant · 2025

Advancing genetic medicines for inherited kidney disease

Chronic kidney disease (CKD) is a leading cause of global mortality, affecting ~13% of global population. Inherited kidney diseases (IKD) are estimated to account for a 30% of CKD cases. Despite the unprecedented development of genetic medicines in the past decades, to date no kidney gene therapy intervention is available. Renal gene therapies have encountered two main barriers: (1) its complex anatomy and function has hampered efficient and specific delivery of genetic therapies to the kidney, and (2) many IKDs are caused by mutations in large genes, and therefore, traditional gene supplementation strategies using efficient and safe in vivo vectors (such as adeno-associated viral vectors…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.