Clerbaux Lab

University of Louvain

Région wallonne (BE3) · Belgium

ERC-funded
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ERC Starting Grant · 2025

Human-based methodologies to study toxicity of food nanoparticles on fatty liver diseases via the microbiota-bile acid axis.

Daily ingestion of nanoparticles (NPs) is inevitable due to their wide use by the food sector, some as bactericidal agents. But their antimicrobial effects towards our gut bacteria remain largely unknown. While some studies investigated their impact on microbial composition, very few explored microbial functional changes and significance for host health. It is alarming that our gut microbiome, unanimously recognized as central in many diseases, is currently overlooked in nanotoxicology. Among key roles of microbiota, we and others underlined that secondary bile acids (BA), generated by the gut bacteria, regulate inflammation in the liver by interacting with host receptors. We showed in mice…

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