Mecê Lab

Research focus

ERC Starting Grant · 2025

Multi-modal Imaging for Retinal Analysis at Cellular Levels in Early Alzheimer’s Disease

Neurovascular coupling (NVC) regulates blood flow to meet the metabolic demands of neural activity by delivering oxygen and nutrients. Its dysfunction is a hallmark of several neurological disorders, including Alzheimer’s disease (AD), where early NVC impairment contributes to disease progression. As the retina is the only optically accessible part of the central nervous system, it provides a unique opportunity to investigate NVC at the cellular level. A precise understanding of retinal NVC could uncover key biomarkers for the evaluation of AD progression and the development of new targeted therapies. However, current imaging tools lack the spatial and temporal resolution necessary to…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.