Ohnmacht Lab

Research focus

ERC Starting Grant · 2016

Mucosal Tolerance and Allergic Predisposition: Does it all start in the gut?

Currently, more than 30% of all Europeans suffer from one or more allergic disorder but treatment is still mostly symptomatic due to a lack of understanding the underlying causality. Allergies are caused by type 2 immune responses triggered by recognition of harmless antigens. Both genetic and environmental factors have been proposed to favour allergic predisposition and both factors have a huge impact on the symbiotic microbiota and the intestinal immune system. Recently we and others showed that the transcription factor ROR(γt) seems to play a key role in mucosal tolerance in the gut and also regulates intestinal type 2 immune responses. Based on these results I postulate two major events…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.