ERC Consolidator Grant · 2017
Mechanism and function of gasdermin-induced inflammatory cell death
Pyroptosis is a lytic pro-inflammatory type of programmed cell death that is induced by inflammatory caspases, a family of proteases that control the innate immune response to infection, injury or noxious substances. Inflammatory caspases are activated within so-called inflammasomes, cytosolic signalling platforms that are assembled by pattern recognition receptors upon the detection of pathogen- or host-derived danger signals. Pyroptosis is essential for antimicrobial host defense, but also promotes the concomitant release of inflammatory danger signals and leaderless cytokines that is detrimental during chronic inflammatory disease. Recently it was found that pyroptosis is caused by the…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.